The search for new rapid diagnostic tests (RDT) for malaria is a priority to fight this endemic disease, according to WHO recommendations. In this seminar I report on a new, easy to operate, lab-on-chip diagnostic test, TMek, for the quantification of the plasmodium parasitemia, which could improve malaria diagnostics. The method is based on the paramagnetic susceptibility of hemozoin crystals (the malaria pigment produced by plasmodium as by-product of hemoglobin degradation) which are found within the infected red blood cells and free in the blood. TMek has been first tested at Sacco Hospital (Milano) on control blood samples from healthy donors as well on some samples from patients affected by malaria, diagnosed by haemoscopy and LAMP (Malaria Illumigene – Meridian EU). The test turned out to have a limit of detection for parasitaemia around 0.0002%, 20 times better than currently used RDT, associated with an execution time of just 10 minutes, to be compared with the 20 min of commercial RDT.
See more at the ICMAB website: http://icmab.es/online-seminar-magnetism-fight-for-health-tmek-a-quantitative-lab-on-chip-rapid-diagnostic-test-for-malaria-by-riccardo-bertacco-mon-20-april-2020